As part of a recently awarded EPSRC grant, we are seeking a microbiology student with excellent practical laboratory skills to develop a range of infection models; including skin, wound and cornea, and evaluate these with photodynamic therapy (PDT), imaging and sensing techniques utilising low-cost devices built within the broader project. Experience in biofilm culture and imaging would be beneficial.
The applicant will be placed within a dynamic, multidisciplinary team of chemists, engineers, biologists and clinicians based at Queen’s Medical Research Institute (in the Centre for Inflammation Research), and work closely with our partners in India and Africa. Together we are working to develop point-of-care diagnostic and treatment platforms for low resource settings
Supervised by: Professor Kev Dhaliwal and Dr Beth Mills
Closing date: 14 June 2020
Applicants should also arrange for two academic referees to submit letters of reference via email before the deadline. All documents should be submitted no later than 5pm on Sunday 14 June 2020. Short-listed candidates will be notified by email. Informal enquiries can be sent via email to firstname.lastname@example.org
Applicants should submit the following documents to CIR.Postgraduate@ed.ac.uk : (i) Personal statement about their research interests and their reasons for applying; and (ii) CV.
Visit the page on findaphd.com and send an email: Targeted Anti-Microbial Photodynamic Therapy: infection model development and evaluation
The EPSRC IRC Proteus (Proteus) – Multiplexed ’Touch and Tell’ Optical Molecular Sensing and Imaging – Lifetime and Beyond” is an Interdisciplinary Research Collaboration between the Universities of Edinburgh, Bath, Heriot Watt, Durham and Dundee.
This highly interdisciplinary collaboration is focused on sensing and imaging for improved clinical care with researchers from the fields of optical fibres, detectors, fluorescent probes, biological models, signal processing and machine learning. Based on the initial research developments testing in patients has commenced of a number of world-leading bedside-based technology platforms to diagnose disease inside the lung. This project is to help develop the next generation of instruments suitable for longer term use in the clinic.
This Optical Sensing and Imaging Platform is providing ground-breaking dynamic sensing of pathological events in the distal lung of patients at the molecular level, which leads to significant healthcare improvement through rapid diagnosis, patient stratification and personalised drug therapy. The platform consists of both optical fibre-bundle and bench-top microscopy imaging systems, and time-resolved fluorescence/Raman spectroscopy systems.
The PhD project is focused on taking our most recent detector, the world’s first distal chip-on-tip camera capable of fluorescence lifetime imaging based on state of the art stacked 3D CMOS single photon detectors, and looking to integrate this with miniature optics, spectroscopy systems and advanced control software. We expect this technology will improve the specificity of identifying disease states over today’s intensity-based microendoscopy cameras and now seek to recruit a high-calibre postgraduate student to take this technology from board level prototype to optic fiber mounted microendoscopy imaging system towards in-vivo trials. The student will gain experience in applications of novel SPAD detectors, miniature optics and fibre integration, working with chemists, biologists and clinicians as well as software and data analysis.
You will join a team in Engineering and Clinical Sciences at University of Edinburgh’s and work in close collaboration with optical physicists in the Centre for Advanced Instrumentation at Durham University (Prof John Girkin) with opportunities for exchange visits between the sites. This project would suit students with a background in physics or engineering with strong practical skills in optics, mechanics or signal/image processing, an interest in software, chemical biology and bio-photonics would be an advantage and experience in multidisciplinary research would also be beneficial.
Supervised by: Professor Robert K Henderson and Dr Neil Finlayson
Closing date: 30 June 2020
Visit the page on findaphd.com and send an email: Fluorescence Lifetime Micro-endoscopic Camera System for Clinical Optical Imaging