Current Vacancies

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Four PhD students vacancies – various locations

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University of Edinburgh: PhD Studentship in Targeted Anti-Microbial Photodynamic Therapy: infection model development and evaluation

  • Role

    PhD student

  • Project title

    Targeted Anti-Microbial Photodynamic Therapy: infection model development and evaluation

  • Location

    College of Medicine and Veterinary Medicine, University of Edinburgh

  • Line Manager

    Professor Kev Dhaliwal and Dr Beth Mills

  • Minimum qualification

    An upper second class degree or equivalent in a relevant discipline.

  • Contract

    48 months (fixed term)

  • Salary

    Stipend and tuition fees at the UK/EU rate, as well as contributions towards travel and research costs for their PhD project.

  • Application deadline

    14 June 2020

Project description:

As part of a recently awarded EPSRC grant, we are seeking a microbiology student with excellent practical laboratory skills to develop a range of infection models; including skin, wound and cornea, and evaluate these with photodynamic therapy (PDT), imaging and sensing techniques utilising low-cost devices built within the broader project. Experience in biofilm culture and imaging would be beneficial.

The applicant will be placed within a dynamic, multidisciplinary team of chemists, engineers, biologists and clinicians based at Queen’s Medical Research Institute (in the Centre for Inflammation Research), and work closely with our partners in India and Africa. Together we are working to develop point-of-care diagnostic and treatment platforms for low resource settings

Supervised by: Professor Kev Dhaliwal and Dr Beth Mills

Closing date: 14 June 2020

References:

Applicants should also arrange for two academic referees to submit letters of reference via email before the deadline. All documents should be submitted no later than 5pm on Sunday 14 June 2020. Short-listed candidates will be notified by email. Informal enquiries can be sent via email to beth.mills@ed.ac.uk

Application Procedure:

Applicants should submit the following documents to : (i) Personal statement about their research interests and their reasons for applying; and (ii) CV.

Visit the page on findaphd.com and send an email: Targeted Anti-Microbial Photodynamic Therapy: infection model development and evaluation

University of Edinburgh: PhD Studentship in Fluorescence Lifetime Micro-endoscopic Camera System for Clinical Optical Imaging

  • Role

    PhD student

  • Project title

    Fluorescence Lifetime Micro-endoscopic Camera System for Clinical Optical Imaging

  • Location

    School of Engineering, University of Edinburgh

  • Line Manager

    Professor Robert K Henderson and Dr Neil Robertson

  • Minimum qualification

    An Honours degree at 2:1 or above (or International equivalent) in a relevant science or engineering discipline, possibly supported by an MSc Degree.

  • Contract

    36 months (fixed term)

  • Salary

    Tuition fees + stipend available for Home students and EU students who have been resident in the UK for 3+ years.

  • Application deadline

    30 June 2020

Project description:

The EPSRC IRC Proteus (Proteus) – Multiplexed ’Touch and Tell’ Optical Molecular Sensing and Imaging – Lifetime and Beyond” is an Interdisciplinary Research Collaboration between the Universities of Edinburgh, Bath, Heriot Watt, Durham and Dundee.

This highly interdisciplinary collaboration is focused on sensing and imaging for improved clinical care with researchers from the fields of optical fibres, detectors, fluorescent probes, biological models, signal processing and machine learning. Based on the initial research developments testing in patients has commenced of a number of world-leading bedside-based technology platforms to diagnose disease inside the lung. This project is to help develop the next generation of instruments suitable for longer term use in the clinic.

This Optical Sensing and Imaging Platform is providing ground-breaking dynamic sensing of pathological events in the distal lung of patients at the molecular level, which leads to significant healthcare improvement through rapid diagnosis, patient stratification and personalised drug therapy. The platform consists of both optical fibre-bundle and bench-top microscopy imaging systems, and time-resolved fluorescence/Raman spectroscopy systems.

The PhD project is focused on taking our most recent detector, the world’s first distal chip-on-tip camera capable of fluorescence lifetime imaging based on state of the art stacked 3D CMOS single photon detectors, and looking to integrate this with miniature optics, spectroscopy systems and advanced control software. We expect this technology will improve the specificity of identifying disease states over today’s intensity-based microendoscopy cameras and now seek to recruit a high-calibre postgraduate student to take this technology from board level prototype to optic fiber mounted microendoscopy imaging system towards in-vivo trials. The student will gain experience in applications of novel SPAD detectors, miniature optics and fibre integration, working with chemists, biologists and clinicians as well as software and data analysis.

You will join a team in Engineering and Clinical Sciences at University of Edinburgh’s and work in close collaboration with optical physicists in the Centre for Advanced Instrumentation at Durham University (Prof John Girkin) with opportunities for exchange visits between the sites. This project would suit students with a background in physics or engineering with strong practical skills in optics, mechanics or signal/image processing, an interest in software, chemical biology and bio-photonics would be an advantage and experience in multidisciplinary research would also be beneficial.

Supervised by: Professor Robert K Henderson and Dr Neil Finlayson

Closing date: 30 June 2020

Application Procedure:

Visit the page on findaphd.com and send an email: Fluorescence Lifetime Micro-endoscopic Camera System for Clinical Optical Imaging

University of Dundee: PhD Studentship in Photonics Tools to Observe Cells In Action In Vivo, In Situ, In Patients – Enabling Future Discovery

  • Role

    PhD student

  • Project title

    Photonics Tools to Observe Cells In Action In Vivo, In Situ, In Patients – Enabling Future Discovery

  • Location

    School of Science and Engineering, University of Dundee

  • Line Manager

    Dr N Krstajik and Professor G Nabi

  • Contract

    36 months (fixed term)

  • Salary

    Tuition fees + stipend available for Home students and EU students who have been resident in the UK for 3+ years.

  • Application deadline

    30 June 2020

Project description:

Imaging quality in endomicroscopy focuses on optics but the crucial areas of real-time software development and human perceptual error are largely ignored. New methods like endomicroscopy stand to gain from improved understanding of what images represent in terms of both perceived and physical depth, focus, blur and associated potential for misdiagnosis. Full understanding of endoscopic imaging in terms of optics, software and perception is lacking. Our ambition for this interdisciplinary studentship (via engineering, physics, clinical and vision science co-supervisors) is multifaceted: 1) we propose a set of translational photonics solutions to improve the spatial resolution of endomicroscopy; 2) we push for real-time software developments which enhance image quality; 3) we quantify perceptual errors. The PhD student will design new endomicroscopy probes (e.g. fibre-bundle or chip-on-tip based) to enhance the spatial resolution of existing ones while ensuring in vivo clinical option is maintained. Using this enhanced system with associated software we will discover the dominant perceptual errors (and how to minimise them). We also propose to study the feasibility of exploiting inherent motion in tissue with high frame-rate imaging to deliver enhanced 3D perception [3]. Finally, low-cost options for engineering a smaller and more portable system will be explored. We are looking for ambitious PhD student to attack challenging technical issues across multiple disciplines but with focus on medical device design.

Interested applicant should send an email to Dr Krstajic with a CV and cover letter.

References
1. N. Krstajic, et al “Two-color widefield fluorescence microendoscopy enables multiplexed molecular imaging in the alveolar space of human lung tissue,” Journal of Biomedical Optics 21, (2016).
2. N. Krstajic, et al “Low-Cost High Sensitivity Pulsed Endomicroscopy to Visualize Tri-Color Optical Signatures,” Journal of Biomedical Optics, 23, (2018).
3. Giesel, M et alInvestigating Human Visual Sensitivity to Binocular Motion-in-Depth for Anti- and De-Correlated Random-Dot Stimuli. Vision 2018, 2, 41.

Supervised by: Dr N Krstajik and Professor G Nabi

Closing date: 30 June 2020

Application Procedure:

Visit the page on findaphd.com and send an email: Photonics Tools to Observe Cells In Action In Vivo, In Situ, In Patients – Enabling Future Discovery

Heriot Watt University: PhD Studentship in Application of Deep Learning for Clinical Imaging

  • Role

    PhD student

  • Project title

    Application of Deep Learning for Clinical Optical Imaging

  • Location

    School of Engineering and Physical Sciences, Heriot Watt University

  • Line Manager

    Dr Marta Vallejo

  • Minimum qualification

    MSc (or near completion) in Machine Learning, Artificial Intelligence or a closely related area.

  • Contract

    36 months (fixed term)

  • Salary

    Tuition fees + stipend available for Home students and EU students who have been resident in the UK for 3+ years.

  • Application deadline

    Applications accepted all year round

Project description:

We are looking for a highly motivated prospective PhD student to undergo a 3-year fully-funded PhD position in the area of machine learning and deep learning theory and applications. The appointee will join the Institute of Sensors and Signals and Systems (ISSS) in the group of Dr Marta Vallejo at Heriot-Watt University. ISSS is one of five Research Institutes in the School of Engineering and Physical Sciences and carries out a broad range of world-leading research in sensors, systems and signal processing.

The successful candidate will join the high profile EPSRC-funded “Proteus” interdisciplinary research collaboration (proteus.ac.uk) – a collaboration involving Heriot-Watt University, and the Universities of Edinburgh, Bath and Durham. The overarching vision of Proteus is to develop a game-changing approach to the treatment of critically ill respiratory patients using advanced microendoscopic imaging and sensing technologies to more accurately guide the care pathway.

Deep Learning theory has seen an immense development in the past few years across a number of areas in medical image analysis, such as diagnosis, registration and segmentation. However, their use in biomedicine is limited by their lack of interpretability and explainability, their unquantified robustness, and their requirements of large amounts of training data. The possible areas of interest of the position include the design of better segmentation and registration algorithms using deep learning techniques, and the development of algorithms for the extraction of biomarkers and classification. The machine learning work will also include developing methods that can explain the decision made by the models. The area of neuroevolution could be also considered.

Supervised by: Dr Marta Vallejo

Closing date: until position filled

Application Procedure:

Visit the page on findaphd.com and send an email: Application of Deep Learning for Clinical Optical Imaging