EPSRC IRC —Multiplexed Optical
Molecular Sensing and Imaging

Lighting up the Lung — Detecting Disease



The lungs are susceptible to infection and scarring which may limit their ability to help us breathe. Molecular imaging can be used to help understand the processes of infection and scarring in the lungs and to treat patients more effectively.

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Catch up with all of the latest PROTEUS news. Meet the scientists who work at the forefront of this evolving and exciting discipline.

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We have many upcoming opportunities for you to participate in. Events which allow you to meet others and share your interests as well a training events which enable you to update your skills and knowledge.

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Looking for insights and inspiration? We have developed a wide range of resources and activities for you to use. Please dip into our toolkit, read a case study or watch a video, there is something for everyone.

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We are really keen to hear your thoughts and encourage your participation. Join us as we work towards better understanding lung disease and diagnostic technologies.

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4 September 2016

Photon16 Conference 2016

PROTEUS engineers and physicists will attend the IOP Institute of Physics Photon16 Conference next week.

Photon16 is the largest optics and photonics conference in the UK. Over four days, PROTEUS researchers will have the opportunity to visit exhibitions on the latest in optics and photonics technology, attend lectures from experts in the field, and get up to date with cutting-edge research.

They will also share PROTEUS science through oral and poster presentations.

Michael Tanner
Type of presentation: Oral
Title: Multiplexed fibre optic sensing in the distal lung
When: 6th September 17.00

Kerrianne Harrington
Type of presentation: Oral
Title: Reducing crosstalk in multicore fibres with parabolic index profiles
When: 5th September 15.15

Helen Parker
Type of presentation: Poster
Title: Imaging and spectroscopic data of pathologies in the distal lung using coherent fibre bundles
When: 5th September

Katjana Ehrlich
Type of presentation: Poster
Title: Time resolved spectroscopy with advanced CMOS single photon detector arrays for disease diagnosis in the distal lung
When: 5th September

Debaditya Choudhury
Type of presentation: Poster
Title: ISensing physiology in the distal lung
When: 5th September

James Stone
Type of presentation: Poster
Title: New designs for imaging fibres
When: 5th September

Vikram Kamaljith
Type of presentation: Poster
Title: Development of multifunctional fluorescence based endoscopic sensors for medical applications
When: 5th September

Harry Wood
Type of presentation: Oral
Title: Quantitative characterisation of endoscopic imaging fibres
When: 4th September

Find out more about the Photon16

8 September 2016

PROTEUS Science at the World Molecular Imaging Congress 2016

PROTEUS researchers will give oral and poster presentations at the World Molecular Imaging Congress 2016 (WMIC).

The World Molecular Imaging Congress is organized by the World Molecular Imaging Society (WMIS) and is led by senior academic and industry professionals who have widely recognized expertise in molecular imaging.

PROTEUS scientists are delighted that they have been selected to travel to New York, USA next week to share their science at such a prestigious meeting. They look forward to hearing from researchers across the world about what is new and relevant in the field of molecular imaging.

Ahsan Akram
Type of presentation: Oral
Title: An optical molecular imaging strategy utilising fluorescently labelled anti-microbial peptides for the in situ detection of bacteria in the human lung.
When: 8th September 1.45pm

Emma Scholefield
Type of presentation: Poster
Title: Rapid clinical–grade optical imaging agent development- A Quality System approach in an academic environment
When: 9th September 4-5pm

Alicia Megia Fernandez
Type of presentation: Poster
Title: Fluorogenic dual-probes for the simultaneous detection of proteases with biomedical importance at two wavelengths.
When: 9th September 4-5pm

Beth Mills
Type of presentation: Oral
Title: Optical detection of matrix metalloproteinases in pulmonary fibrosis using optical endomicroscopy in the distal lung.
When: 8th September 12pm

Tom Craven
Type of presentation: Poster
Title: In vitro, ex vivo and in vivo imaging of neutrophil activation in the alveolar space using pulmonary optical endomicroscopy and a bespoke molecular imaging probe
When: 9th September 4-5pm

Find out more about the WMIC

10 September 2016

PROTEUS Are Going To The British Science Festival 2016!

PROTEUS will be enthusiastically sharing our science at The British Science Festival Family Weekend 2016 so come along and join in!

The British Science Festival Family Weekend will be held in Swansea and hosted by Swansea University on 10 & 11 September 2016.

The Family Weekend will celebrate science in its broadest context and shine a light on the region's innovation, culture and heritage. The events and activities will take place in the heart of the City of Swansea.

The British Science Festival is Europe's longest-standing national event which connects people with scientists, engineers, technologists and social scientists.

Tens of thousands of people come together to celebrate the latest developments in science and to engage in open discussion about issues that affect our culture and society.

PROTEUS' mission to Light up the Lungs to Detect Disease will form a key part of the weekend's activities.

We will invite visitors to step inside our critical care ward and help PROTEUS doctors make very important decisions about their patient’s health.

Visitors will use our brilliant optic fibres to look deep into the patient’s lungs and find the bugs causing illness then help the team choose the correct medicine to give to get our patient back on his feet and well again.

Find out more about the British Science Festival

News & Views

08 September 2016

Dr Bethany Mills wins Women in Molecular Imaging Network Scholar Award

Dr Bethany Mills has been awarded the Women in Molecular Imaging Network Scholar Award at the World Molecular Imaging Congress today.

Beth's research looking at how scarring of lung tissue can be identified using PROTEUS technology has been recognised and highly praised by the Women in Molecular Imaging Network Interest Group.

Beth will be honoured at an Award Luncheon today and receive a prize of $350. PROTEUS team members are incredibly proud of Beth's achievement and hope she enjoys her well deserved award and continues to deliver excellent science in the future.

Find out more about the Beth's PROTEUS research

Beth's academic background

What is the World Molecular Imaging Congress?

01 August 2016

PROTEUS Prepares for First Clinical Study

Dr Annya Symth, PROTEUS' Clinical Study Manager talks us through PROTEUS' first clinical study and explains the challenges that lie ahead.

What are your responsibilities in PROTEUS?

I am responsible for managing the design, set-up and running of the clinical studies that test both the optical Smartprobes and the evolving technology. This includes designing and developing the clinical protocols alongside the lead clinicians, obtaining the necessary approvals and working closely with the Sponsor and clinical staff to ensure the study runs smoothly. I’ve also renewed my research passport to help our clinical team in the hospital to carry out the research, if it’s needed. It’s a great chance to meet the patients involved and to make sure the studies we design in our office actually work well in a clinical environment.

The process of bringing PROTEUS into commercial use is incredibly complex - can you walk us through the protocol?

The ultimate aim of the PROTEUS project is to develop technology that is accessible to clinicians worldwide, but this is a few years off. Right now we are running small, local studies to test the individual components of the technology, but we’ll eventually conduct a large regulated clinical trial to obtain valuable data about the functionality of the final imaging platform prior to potential commercialisation.

What stage of this process are PROTEUS at now?

The PROTEUS project is about halfway through its journey-we are now at the stage of our first clinical study that’s due to start in July 2016. The end goal of the project, in June 2018, is to test the fully functioning Smartprobe delivery, imaging and sensing system for the first time in humans.

Why is this clinical study important?

So far we have tested and evaluated our imaging system in animal lungs and now we are at the stage of moving the technology into humans. We want to develop a novel approach to address the unmet needs of identifying and measuring pulmonary fibroproliferative pathway.

What’s the biggest challenge you’ve faced bringing PROTEUS to its first clinical study?

The biggest challenge to date, and I honestly don’t think it’s a challenge in the true sense of the word, is to ensure that those involved in working with us and approving the Versicolour device and Smartprobes for clinical use are a fully integrated part of this journey, and appreciate the low risk nature of the technology. We’ve already demonstrated that the Smartprobe and device are safe for clinical use, but the novel approach that we’re using and the state-of-the-art technology will always challenge existing perceptions which are based around more conventional research tools that are currently in use.

What challenges lie ahead?

A potential challenge that I can see in the future is the integration of the sensors to our technology. In saying that, the team have come a long way so far and are well capable of jumping any possible technical hurdles.

Interview conducted by Kate Boyd Crotty and Jessica Davis, Science Communication Mater Students

Read Annya's Full Interview

22 April 2016

EPSRC: Interdisciplinary Research is Critical to Success

Healthcare innovations need world-leading research and skilled people to get off the ground. Cross discipline collaborations, including those funded by the Engineering and Physical Sciences Research Council (EPSRC), are critical to success.

01 January 2016

EPSRC Very Supportive of PROTEUS' Progress

We invite you to read PROTEUS' Mid Term Review Brochure which summarizes all of our hard work over the last 2.5 years.

PROTEUS' funding body, The Engineering and Physical Sciences Research Council has confirmed that the mid-term review panel were very supportive of the progress that PROTEUS has made to date.

PROTEUS are delighted, a great way to end a successful year!